On the selectivity of deprotection of benzyl, mpm (4-methoxybenzyl) and dmpm (3,4-dimethoxybenzyl) protecting groups for hydroxy functions

Add time:07/16/2019    Source:sciencedirect.com

The 4-methoxybenzyl (MPM) protecting group for hydroxy functions is readily removed with DDQ in dichloromethane containing a small amount of water at room temperature. Under these neutral conditions, several other protecting and functional groups remained unchanged. 3,4-Dimethoxybenzyl (DMPM) groups are more reactive than MPM groups with DDQ. The benzyl (Bn) protecting group was removed by catalytic hydrogenation over Raney nickel. Selective deprotection of DMPM, MPM and Bn groups is also presented.

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