Deglycosylation and absorption of marein, flavanomarein and taxifolin-7-O-β-D-glucopyranoside from capitula of Coreopsis tinctoria in rats and humans

Add time:07/16/2019    Source:sciencedirect.com

Marein, flavanomarein and taxifolin-7-O-β-D-glucopyranoside (TDG) are functional compounds in capitula of Coreopsis tinctoria (CCT). This study demonstrated the above glycosides could be partially deglycosylated to okanin, isookanin and taxifolin, respectively, in cell free extracts from rat and human small intestine, human colon, but not from stomach and cecum. Okanin and isookanin mainly occurred as glucuronide conjugates; whereas taxifolin was in sulfate in rat plasma. The exposures of the glycosides and aglycones were positively correlated with the dosages of CCT extract in rats after oral administration. The aglycones but not glycosides were detected in the plasma of healthy volunteers after intake of CCT (2.5 g/50 kg) water solution. In conclusion, marein, flavanomarein and TDG could be deglycosylated to respective aglycones in gastrointestinal tracts, which could be absorbed and biotransformed to glucuronide or sulfate conjugates. The results will help us to better understand the function and functional components of CCT in vivo.

We also recommend Trading Suppliers and Manufacturers of TAXIFOLIN 3-O-RHAMNOSIDE (cas 11027-89-7). Pls Click Website Link as below: cas 11027-89-7 suppliers

Prev:Isolation and structural characterization of 2R, 3R TAXIFOLIN 3-O-RHAMNOSIDE (cas 11027-89-7) from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats
Next:Naturally-occurring acetylenic compounds and derivatives)