A specific fluorescent probe for zinc ion based on Thymolphthalein (cas 125-20-2) and it’s application in living cells

Add time:09/08/2019    Source:sciencedirect.com

Many diseases are connected with chemical substances, zinc ion is most important ion in chemical substances, because zinc ion (Zn2+) has been shown extensively involved in various physiological and pathological processes. In this work, Thymolphthalein (cas 125-20-2) with good biocompatibility was introduced, the probe was constructed with interweaved benzimidazole and phenol from into the fluorophore system, hydroxyl and amino creating a multipoint binding pocket, which zinc can coordinate in a cooperative breaking Excited-State Intramolecular Proton Transfer, ESIPT. The fluorescence of this probe adding Zn2+ showed an obvious “turn on” in a quick response within 5 s. In addition, the probe had a good selectivity for zinc ion over other analytes. Furthermore, we also studied the fluorescence imaging of probe in the presence of Zn2+ in living A549 cells.

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