Enkephalin analogues and naloxone modulate the release of growth hormone and prolactin - evidence for regulation by an endogenous opioid peptide in brain

Add time:09/26/2019    Source:sciencedirect.com

Met5-enkephalin amide, D-Ala2-Met5-enkephalin amide, D-Ala2-Leu5-enkephalin amide, morphine sulfate and naloxone hydrochloride were examined for their effects on growth hormone and prolactin release invivo and invitro. Subcutaneous injection of D-Ala2-Met5 enkephalin amidea, D-Ala2-Leu5 enkephalin amideb and morphine sulfate, but not Met5-enkephalin and amidec, resulted in significant elevations in the serum growth hormone and prolactin of immature female rats. Naloxone blocked the hormone-stimulatory effect of the opioid receptor agonists and when administered alone significantly reduced serum growth hormone and prolactin concentrations. None of the drugs demonstrated a direct action on anterior pituitary tissue growth hormone or prolactin release invitro.

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