An efficient chemoenzymatic approach to enantiomerically pure 4-[2-(difluoromethoxy)phenyl] substituted 1,4-dihydropyridine-3,5-dicarboxylates
-
Add time:07/15/2019 Source:sciencedirect.com
An efficient chemoenzymatic synthesis of (−)-3-methyl 5-(2-propoxyethyl) (4R)-4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate has been achieved. The key step is a highly stereoselective Candida rugosa lipase (CRL)-mediated asymmetrisation of the prochiral bis[(isobutyryloxy)methyl]-4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate.
We also recommend Trading Suppliers and Manufacturers of 1-(4-(difluoroMethoxy)phenyl)-2-phenylethanone (cas 83882-61-5). Pls Click Website Link as below: cas 83882-61-5 suppliers
Prev:Solvent induced morphology evolution from microrods to monodispersed microspheres based on 1,2-diphenyl-4-(4-methoxyphenyl)-1,3-cyclopentadiene
Next:An efficient synthesis of multisubstituted 4-nitrobuta-1,3-dien-1-amines and application in cyclisation reactions) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings07/18/2019
- A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation07/17/2019
- An efficient synthesis of multisubstituted 4-nitrobuta-1,3-dien-1-amines and application in cyclisation reactions07/16/2019
