Enzymatic preparation of isomerically pure 1,4:3,6-dianhydro-D-glucitol monoacetates - precursors for isoglucitol 2- and 5-mononitrates

Add time:09/10/2019    Source:sciencedirect.com

Using a highly selective lipase from Pseudomonas sp. (SAM II) the isomerically pure title compounds 3 and 4 were prepared either by enzymatic hydrolysis (alcoholysis) of the diacetate 2 or by enzymatic esterification of the diol 1, respectively. They were futher converted into the pharmaceutically important, isomerically pure 1,4:3,6-dianhydro-D-glucitol-2- and 5-nitrates 6 and 7.

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