Aromatic carboxylic acids as farnesyl surrogates in FARNESYLPYROPHOSPHATE (cas 13058-04-3)-based farnesyltransferase inhibitors

Add time:09/10/2019    Source:sciencedirect.com

With the help of easily obtainable N-acylaspartic acids, the 4-phenylcinnamoyl and the 4-benzyloxycinnamoyl moiety were identified as structurally simple, readily available farnesyl surrogates, yielding more potent inhibitors of farnesyltransferase than the literature known N-farnesoylaspartic acid.

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