6-SULFANILAMIDOINDAZOLE (cas 13744-68-8) arthritis: Influence of alloxan diabetes, phenylbutazone and D-penicillamine on inflammatory size, sulfhydryl groups, diphenylamine reaction and enzymes of the serum

Add time:09/10/2019    Source:sciencedirect.com

The influence of alloxan diabetes, phenylbutazone (20 mg/kg), and D-penicillamine (30 mg/kg) on 6-SULFANILAMIDOINDAZOLE (cas 13744-68-8) arthritis was investigated. Arthritis was not altered by the alloxan-diabetic stage neither by injecting alloxan during developing arthritis nor by injecting it before the beginning of 6-sulfanilamidoindazole administration. However, the arthritis was completely suppressed by phenylbutazone after both methods of administration. D-penicillamine was without significant effect. Decrease of serum sulfhydryl groups and increase of serum diphenylamine value occurring during arthritis were prevented by phenylbutazone whereas alloxan and D-penicillamine did not.

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