Analytical properties of the amidoxime group: VIII. Synthesis, spectral properties, potentiometric and thermometric behaviour of 3,5-dimethyl, 3-phenyl-5-methyl and 3,5-diphenyl-4-isoxazolylamidoxime

Add time:09/08/2019    Source:sciencedirect.com

Three 4-isoxazolyl-3,5-disubstituted amidoximes have been obtained and several of their physicochemical properties have been studied. The pKa values have been potentiometrically determined, with each amidoxime having two protonation constants, one for low pH values (pKa 2.24–2.96), and one for high pH values (pKa 11.55–12.06).The thermometric behaviour of 3,5-dimethyl-4-isoxazolylamidoxime is studied in an ethanol/water mixture (50%, vv) in order to evaluate the error in its thermometrie titration with HCl and the corresponding neutralization enthalpy at 25°C.

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