Novel Pt(II) and Pt(IV) complexes with 3-amino-5-methyl-5-(4-pyridyl)-2,4-imidazolidenedione. Synthesis, physicochemical, chemometric and pharmacological investigation

Add time:09/08/2019    Source:sciencedirect.com

Platinum(II) and platinum(IV) complexes with 3-amino-5-methyl-5-(4-pyridyl)-2,4-imidazolidenedione (L) with general formulaе cis-[PtL2X2]·nH2O and [PtL2Cl4], where X = Cl−, Br−, I− and n = 2–4) were synthesized. The novel compounds were fully characterized by elemental analysis, IR, 1H, 13C, 195Pt NMR spectra, thermal analysis and molar conductivity. The geometry of Pt(II) complexes and of the organic ligand in the gas phase were optimized using the hybrid DFT method B3LYP with LANL2DZ and 6-31G** basis sets. Some physicochemical parameters as dipole moment, HOMO, LUMO energies and ESP charges were calculated. The comparison of the bond length and angles, obtained from the X-ray analysis and DFT calculations is realized. The cytotoxic effects of these complexes in human T-cell leukemia KE-37 (SKW-3) are reported.

We also recommend Trading Suppliers and Manufacturers of 5-AMINO-3-(4-PYRIDYL)-ISOXAZOLE (cas 19790-96-6). Pls Click Website Link as below: cas 19790-96-6 suppliers

Prev:Molecular Biology of the Carcinogen, 4-Nitroquinoline 1-Oxide
Next:Research paperHighly conjugated systems with pedal motion in uranyl crotonate compounds with 1,2-bis(4-pyridyl)ethylene as a neutral ligand or a counter cation)