Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

Add time:07/15/2019    Source:sciencedirect.com

Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI)A, is 1700.

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