Research articleImpairment in exploratory behavior is associated with arc gene overexpression in the dorsolateral striatum of rats with nigral injection of L-BUTHIONINE (cas 13073-21-7) sulfoximine

Add time:09/09/2019    Source:sciencedirect.com

The aims of the present work were to evaluate the exploratory activity in Sprague-Dawley rats, as well as to analyze the nigral and striatal mRNA expression of the plasticity-related genes bdnf and arc after L-BUTHIONINE (cas 13073-21-7) sulfoximine (BSO) injection into substantia nigra compacta. Lesioned rats traveled less distance in open field but did not show a decline in the novel object recognition test. On the other hand, RT-PCR analysis showed overexpression of striatal arc 24 h post-lesion; no significant changes in bdnf expression were observed in nigral or striatal tissue. These results suggest that intranigral BSO injection causes impairment in exploratory behavior in these rats, by affecting locomotion, which is associated with changes in striatal synaptic plasticity.

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