CommunicationsThe Spatial Structure of the Class II L-Fuculose (cas 13074-08-3)-1-phosphate Aldolase from Escherichia coli

Add time:09/27/2019    Source:sciencedirect.com

The three-dimensional structure of l-fuculose-1-phosphate aldolase (FucA) from Escherichia coli was determined by X-ray crystallography at a resolution of 2.13 Å. The enzyme is a homotetramer with an Mr of 23,775 per subunit. Since its activity depends on the presence of metal ions (Zn2+) the enzyme belongs to the class II aldolases. As expected from amino acid sequence comparisons, this first structure of a class II aldolase shows no similarity to the known structures of class I aldolases. It has some unusual features concerning the overall chain fold, the quarternary structure, and the co-ordination of the catalytically active zinc ion. A sequence comparison with the data bank indicated that the middle domain of the enzyme l-ribulose-5-phosphate-4-epimerase is homologous to FucA and may contain an active-center metal ion.

We also recommend Trading Suppliers and Manufacturers of L-Fuculose (cas 13074-08-3). Pls Click Website Link as below: cas 13074-08-3 suppliers

Prev:Regular articleStructures of L-Fuculose (cas 13074-08-3)-1-phosphate aldolase mutants outlining motions during catalysis1
Next:Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-AMINOADAMANTANE (cas 13074-39-0)s and analogues)