Racemization free longer N-terminal peptide hydroxamate synthesis on solid support using ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate
-
Add time:09/25/2019 Source:sciencedirect.com
A facile, efficient, racemization-free, and environment friendly protocol for the synthesis of peptide hydroxamic acids directly from carboxylic/amino acids by ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate in the presence of DIPEA/DMAP at room temperature is described. The compatibility of this method with Fmoc based solid phase peptide synthesis (SPPS) is also demonstrated by synthesizing three relatively large N-terminal peptide hydroxamic acids on resin. Also, some biologically important hydroxamates are synthesized using this protocol.
We also recommend Trading Suppliers and Manufacturers of tert-Butyl cyanoacetate (cas 1116-98-9). Pls Click Website Link as below: cas 1116-98-9 suppliers
Prev:Arylation of diethyl malonate and ethyl cyanoacetate catalyzed by palladium/di-tert-butylneopentylphosphine
Next:The molecular diversity of three-component reactions of 4-dimethylamino- or 4-methoxypyridine with acetylenedicarboxylates and arylidene cyanoacetates) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Research paperCopper(II) complexes with an arylhydrazone of methyl 2-cyanoacetate as effective catalysts in the microwave-assisted oxidation of cyclohexane09/27/2019
- The molecular diversity of three-component reactions of 4-dimethylamino- or 4-methoxypyridine with acetylenedicarboxylates and arylidene cyanoacetates09/26/2019
- Arylation of diethyl malonate and ethyl cyanoacetate catalyzed by palladium/di-tert-butylneopentylphosphine09/24/2019
- Synthesis of aryl nitriles by palladium-assisted cyanation of aryl iodides using tert-butyl isocyanide as cyano source09/10/2019
- Reaction of 3-hetero-1,5-dialdehydes with tert-Butyl cyanoacetate (cas 1116-98-9)☆09/09/2019
-
Health and Chemical more >
-
Related Products
- tert-Butyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetate
- tert-Butyl (1-formylcyclopropyl)carbamate
- tert-Butyl (1-hydroxy-3-phenylpropan-2-yl)carbamate
- tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-carboxylate
- tert-Butyl (2-aminophenyl)carbamate
- tert-Butyl (2-chloro-3-formylpyridin-4-yl)carbamate
- tert-Butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate
- tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
- tert-Butyl (2S)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate
- tert-Butyl (2S)-2-carbamoyl-2,3-dihydropyrrole-1-carboxylate