Asymmetrized trils (hydroxymethyl)methane as a highly stereodivergent chiral building block: preparation of all four stereoisomers of protected 2-hydroxymethyl-1,3-butanediol

Add time:09/25/2019    Source:sciencedirect.com

Monoacetate 3 is a synthetic equivalent of asymmetrized tris (hydroxymethyl)methane 1, which is a new chiral building block endowed with latent C3v symmetry. Thanks to this property, starling from a single enantiomer 3, it is possible to get not only both (R) and (S) aldehydes 7, but also all the stereoisomers deriving from addition of a C-nucleophile to 7, just relying on a single diastereocontrol (double stereodivergency).

We also recommend Trading Suppliers and Manufacturers of 1,3-BUTANEDIOL DIACETATE (cas 1117-31-3). Pls Click Website Link as below: cas 1117-31-3 suppliers

Prev:Reaktionen von aluminiumalkylen mit carbonyl-verbindungen: II. Hydroaluminierung von aldoenolestern—eine Neue 1,3-diolsynthese
Next:Surface modification of poly(ethylene-butyl acrylate) copolymers by microwave methodology and functionalization with 4-dimethylamino-N-(2-hydroxyethyl)-1,8-naphthalimide for acidity sensing)