Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-TERT-BUTYLUREA (cas 1118-12-3) derivatives

Add time:09/09/2019    Source:sciencedirect.com

1-(1H-Benzimidazol-5-yl)-3-tert-butylurea derivatives have been identified as a novel class of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Herein, we disclose the synthesis and structure–activity relationships (SAR) of this class resulting in the identification of compound 12c, with dual functional activity on human and rat receptors (rat LHRH: IC50 = 120 nM; human LHRH: IC50 = 18 nM). These SAR studies suggest that 1-(1H-benzimidazol-5-yl)-3-tert-butylurea is a new pharmacophore for small molecule LHRH antagonists.

We also recommend Trading Suppliers and Manufacturers of TERT-BUTYLUREA (cas 1118-12-3). Pls Click Website Link as below: cas 1118-12-3 suppliers

Prev:The interpretation of the crystal field parameters for fn-electron systems by the angular overlap model. The enneaaquorare-earth ethylsulfates
Next:Interactions in aqueous solutions of alkylureas. Excess enthalpies at 25• for butylurea and its isomers.)