Enzymatic reduction of α-keto acids leading to l-amino acids, d- or l-hydroxy acids
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Add time:09/26/2019 Source:sciencedirect.com
The substrate range of leucine dehydrogenase and phenylalanine dehydrogenase isolated from different organisms was investigated using a range of hydrophobic α-keto acids. Several aliphatic l-amino acids with bulky side chains were synthesized by reductive amination, l-neopentylglycine was produced on 30 kg scale. Besides the reductive amination of the α-keto acids these compounds were also investigated as substrates for hydroxyisocaproate dehydrogenase from Lactobacillus confusus and Lactobacillus casei, respectively.
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