Methods for the determination of the enantiomeric purity of the C3-synthons glycidol (2,3-epoxy-1-propanol) and solketal [2,2-dimethyl-4-(hydroxymethyl)-1,3-dioxolane]

Add time:07/15/2019    Source:sciencedirect.com

Accurate and reliable methods are presented for the determination of enantiomeric excess values of glycidol (2,3-epoxy-1-propanol), glycidyl esters, solketal [2,2-dimethyl-4-(hydroxymethyl)-1,3-dioxolane], homologous 1,3-dioxolane alcohols and substituted primary propanols in biological samples. One method consists of derivatization of the samples with 2,3,4,6-tetra-O-acetyl-β-glucopyranosyl isothiocyanate, followed by separation of the resulting diastereomers on a non-chiral reversed-phase (C18) HPLC column. The second method uses direct injection of (aqueous) samples on to capillary GC columns coated with chiral stationary phases (2,3,6-tri-O-methyl-β- or a 2,3,6-tri-O-trifluoroacetyl-λ-cyclodextrin). The advantages and disadvantages of both methods are discussed.

We also recommend Trading Suppliers and Manufacturers of 3-(3-HYDROXYPROPYL)SOLKETAL (cas 206999-64-6). Pls Click Website Link as below: cas 206999-64-6 suppliers

Prev:Five novel lanthanide complexes with 2-chloroquinoline-4-carboxylic acid and 1,10-phenanthroline: Crystal structures, molecular spectra, thermal properties and bacteriostatic activities
Next:Ceramide 1-(2-cyanoethyl) phosphate enhances store-operated Ca2+ entry in thyroid FRTL-5 cells)