Allylic lithiation of METHYLENECYCLOBUTANE (cas 1120-56-5)s

Add time:09/10/2019    Source:sciencedirect.com

Methylenecyclobutanes undergo a lithiation reaction in the presence of n-BuLi or n-BuLi/KOtBu from −78 °C to room temperature or to 40 °C in THF within 3 h and then quenching with a variety of electrophiles to give the corresponding addition products (alcohols) in moderate to good yields within 2 h. The alcohols can be easily oxidized to the ketones, which can be transformed to the substituted cyclopentenes in the presence of AlCl3 within short reaction time.

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