Tautomeric variety and methylation of 3,6-dihydroxy-4-Methylpyridazine (cas 1120-88-3)

Add time:09/10/2019    Source:sciencedirect.com

The method of exhaustive methylation has been applied for investigating tautomeric stability and its temperature variation of 6-hydroxy-5-methyl-3-pyridazinone (1) and its N-phenyl derivative (2)—two model compounds chosen for studying tautomeric transformations of pyridazine medicinal drugs, either in the process of their production, or then their activity in the living tissue. The resulting N-methylated and O-methylated products were separated, and characterized by 1H NMR and X-ray diffraction. The methylation of 1 and 2 in the dimethyl sulfate as well as in its aqueous solution leads predominantly to the O-methylated forms, but the rising temperature favours the N-methylation.

We also recommend Trading Suppliers and Manufacturers of 4-Methylpyridazine (cas 1120-88-3). Pls Click Website Link as below: cas 1120-88-3 suppliers

Prev:ArticleAn environmentally-friendly base organocatalyzed one-pot strategy for the regioselective synthesis of novel 3,6-diaryl-4-Methylpyridazine (cas 1120-88-3)s
Next:Regular ArticlesEarly Increase in Cyclin-D1 Expression and Accelerated Entry of Mouse Hepatocytes into S Phase after Administration of the Mitogen 1,4-Bis[2-(3,5-Dichloropyridyloxy)] Benzene)