Steroid conjugates. V.1 The synthesis of a suifoglucuronide derivative of estriol

Add time:09/10/2019    Source:sciencedirect.com

The di-potassium salt of estriol-3-sulfate-16-glucuronide [17β-hydroxy-3-sulfooxyestra-l,3,5(lO)-trien-16α-yl-β-=D-glucopyrano-siduronic acid di-potassium salt] (11) has been synthesized by a pathway utilizing the direct condensation of methyl (2,3,-tri-O-acetyl-α-bromo-=D-glucopyranosid)ronate with estriol-3-benzyl ether (2). The structure of this intermediate, methyl (3-benzyloxy-17β-hydroxyestra-l,3,5(lO)-trien-16α-yl-2',3',4'-tri-O-acetyl-β-D-glucopyranosid)ronate (3) was unequivocally confirmed by its synthesis from methyl (3Ubenzyloxyestra-l,3,5(lO)-trien-17-on-16α-yl-2',3',4'-tri-O-acetyl-β-=D-glucopyranosid)ronate (5). Selective removal of the benzyl group followed by sulfation with triethylaminesulfur trioxide afforded the key compound, methyl (17β-acetoxy-3-triethylammoniosulfooxyestra-l,3,5(lO)-trien-16α-yl-2',3',4'-tri-O-acetyl-β-=D-glucopyranosid)ronate (10). Basic hydrolysis gave the sulfoglucuronide as its di-potassium salt.

We also recommend Trading Suppliers and Manufacturers of ESTRIOL 3-BENZYL ETHER (cas 18650-87-8). Pls Click Website Link as below: cas 18650-87-8 suppliers

Prev:The synthesis of estriol 16- and 17-monoglucuronide from estriol
Next:The synthesis and some properties of estriol-15-3H (1))