Mutagenic effect of nitrilotriacetic acid on cultured human cells

Add time:09/10/2019    Source:sciencedirect.com

The mutagenic potential of nitrilotriacetic acid trisodium salt monohydrate (NTA) was evaluated on a human cell line (EUE) using selection for diphtheria toxin (DT) resistance. Cultures were treated with different doses of the chemical (2 × 10−2 − 2 × 10−8 M) for 24 h, and cytotoxicity determined. NTA was effective in inducing diphtheria toxin-resistant (DTR) mutants, at all concentrations tested, except at 2 × 10−6 M.

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