Original articlesSynthesis and evaluation of a new series of 17α-[123I]iodovinyl estradiols

Add time:09/09/2019    Source:sciencedirect.com

A series of 17α-substituted estradiols was synthesized in which the stereochemical characteristics of carbons 20 and 21 were modified. It was found that the (Z)-isomer demonstrated more favorable receptor binding affinity than the corresponding (E)-isomer.

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