Research paperPutative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs)

Add time:09/10/2019    Source:sciencedirect.com

IntroductionThe redox characteristics of 1,2,4-benzotriazine-1,4-dioxides (BTDOs) make them potential radiosensitizing agents for hypoxic cells in solid human cancers. Tirapazamine (TPZ) is the most clinically tested BTDO radiosensitizer, despite its toxicity at effective doses. To date, no BTDOs have been developed as diagnostic markers of tissue hypoxia.

We also recommend Trading Suppliers and Manufacturers of 3-AMINO-7-CHLORO-1,2,4-BENZOTRIAZINE-1-OXIDE (cas 18671-92-6). Pls Click Website Link as below: cas 18671-92-6 suppliers

Prev:DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide
Next:Review articleAn overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds)