Synthesis and biological evaluation of 3-carbamate SMILAGENIN (cas 126-18-1) derivatives as potential neuroprotective agents

Add time:09/09/2019    Source:sciencedirect.com

Studies indicated that SMILAGENIN (cas 126-18-1), isolated from Anemarrhena asphodeloides Bunge, could improve cognitive impairment and exhibit neuroprotective activity. On the basis of the structure of smilagenin, a series of derivatives were synthesized and evaluated for their neuroprotective effects of H2O2-induced, oxygen glucose deprivation-induced neurotoxicity in SH-SY5Y cells and LPS-induced NO production in RAW264.7 cells. Structure activity relationship of derivatives revealed that benzyl-substituted piperazine formate derivatives showed the potent neuroprotective activity such as A12. These findings may provide new insights for the development of neuroprotective agents against Alzheimer’s disease.

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