Novel fluorescent probes for sequential detection of Cu2+ and citrate anion and application in living cell imaging

Add time:09/09/2019    Source:sciencedirect.com

Three novel fluorescent probes (L1, L2 and L3) derived from 2-hydroxyphenyl-4-chloromethyloxazole 8-ydroxyquinaldine were designed and synthesized. The probes showed highly selectively and sensitivity towards Cu2+ ion through “turn off” response in DMF/H2O solution (v/v = 1/1, 0.01 M, Tris-HCl buffer, pH 7.30). The detection limits of probes were up to 8.24 × 10−8 M for Cu2+ ion, which were much lower than drinking water permission concentrations by the United States Environmental Protection Agency. Sequentially, the L1-Cu2+, L2-Cu2+ and L3-Cu2+ complexes detected citrate anion (CA) through “turn on” response. The probes, were also found to be reversible and recyclable toward Cu2+ ion and CA controlled “On–Off–On” fluorescent switch and acted as molecular logic gates. Furthermore, the in vivo sensitivity experiments of Cu2+ ion and CA were demonstrated through fluorescence imaging in living cells.

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