Detoxification of chloroprene (2-Chloro-1,3-butadiene (cas 126-99-8)) with glutathione in the rat
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Add time:10/01/2019 Source:sciencedirect.com
Biotransformation of chloroprene (2-chloro-1,3-butadiene) in the rat or in isolated rat hepatocytes leads to glutathione conjugates with concomitant depletion of hepatic glutathione and increased excretion rates of urinary thioethers. Conjugate formation depends on microsomal enzyme activities suggesting the involvement of an epoxide intermediate.
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