Hydroxyurea (cas 127-07-1) embryotoxicity is enhanced in P53-deficient mice
-
Add time:09/24/2019 Source:sciencedirect.com
Hydroxyurea (cas 127-07-1), a ribonucleotide reductase inhibitor, is a potent teratogen in mice, causing severe limb and skeletal defects. The exposure of gestation day nine murine embryos to hydroxyurea elicits an early embryonic stress response that involves activation of the P53 transcription factor. The impact of this P53 activation on the embryotoxicity of hydroxyurea- is not known. The goal of this study was to test the hypothesis that P53 acts to suppress hydroxyurea embryotoxicity. Trp53+/− timed pregnant mice were treated with saline or hydroxyurea (200 or 400 mg/kg) on gestation day nine; fetuses were examined for viability and external and skeletal malformations on gestation day eighteen. Neither the deletion of Trp53 nor hydroxyurea treatment significantly affected fetal growth although a trend towards a decrease in fetal weights was observed in Trp53-/- fetuses. However, hydroxyurea induced a significantly higher incidence of malformations and resorptions in Trp53-/- fetuses compared to their wildtype littermates. Thus, fetal P53 genotype is an important determinant of the effects of hydroxyurea on organogenesis-stage embryos.
We also recommend Trading Suppliers and Manufacturers of Hydroxyurea (cas 127-07-1). Pls Click Website Link as below: cas 127-07-1 suppliers
Prev:Beliefs about Hydroxyurea (cas 127-07-1) in youth with sickle cell disease
Next:Hydroxyurea (cas 127-07-1): Analytical techniques and quantitative analysis) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Clinical studyCutaneous ulcers associated with Hydroxyurea (cas 127-07-1) therapy09/30/2019
- Real-life experience with Hydroxyurea (cas 127-07-1) in sickle cell disease: A multicenter study in a cohort of patients with heterogeneous descent09/29/2019
- Case StudyMalleolar Ulceration Induced by Hydroxyurea (cas 127-07-1) Therapy for Chronic Eosinophila09/28/2019
- Acute Hydroxyurea (cas 127-07-1) treatment reduces tubular damage following bilateral ischemia-reperfusion injury in a mouse model of sickle cell disease10/01/2019
- Optimising genetic transformation of Trypanosoma cruzi using Hydroxyurea (cas 127-07-1)-induced cell-cycle synchronisation09/27/2019
- p53 mediates Hydroxyurea (cas 127-07-1) resistance in aneuploid cells of colon cancer09/26/2019
- Hydroxyurea (cas 127-07-1): Analytical techniques and quantitative analysis09/25/2019
- Beliefs about Hydroxyurea (cas 127-07-1) in youth with sickle cell disease09/10/2019
- Original ArticlesTargeted Hydroxyurea (cas 127-07-1) Education after an Emergency Department Visit Increases Hydroxyurea (cas 127-07-1) Use in Children with Sickle Cell Anemia09/09/2019