The genetic activity of 6-N-HYDROXYLAMINOPURINE (cas 5667-20-9) in Aspergillus nidulans

Add time:07/15/2019    Source:sciencedirect.com

The activity of a base analog (6-N-hydroxylaminopurine, HAP) has been tested on Aspergillus nidulans. In germinating haploid conidia HAP is a strong mutagen, while it does not have any activity in resting conidia. Moreover, HAP does not increase the frequency of recombination in germinating conidia. The mutagenic activity of this base analog has also been tested in diploid conidia of A. nidulans; in fact, it has been shown (Pavlov et al., 1991) that the HAP-induced frequency of heteroallelic recessive mutations in diploid cells of the yeast S. cerevisiae is higher than expected. In A. nidulans, we did not observe any increase in the frequency of recessive homozygous fpaAfpaA (p-fluorophenylalanine-resistant) mutants over the expected one, which has been calculated on the basis of the observed mutation frequency in the haploid strain.

We also recommend Trading Suppliers and Manufacturers of 6-N-HYDROXYLAMINOPURINE (cas 5667-20-9). Pls Click Website Link as below: cas 5667-20-9 suppliers

Prev:Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists
Next:The reduction of 6-N-HYDROXYLAMINOPURINE (cas 5667-20-9) to adenine by xanthine oxidase)