Lewis acid-mediated cross-coupling reaction of 7-azaindoles and aldehydes: Cytotoxic evaluation of C3-linked bis-7-azaindoles

Add time:09/10/2019    Source:sciencedirect.com

The synthesis of 3,3′-bis-7-indolylmethane derivatives is important for their further development as pharmaceutical compounds and other synthetic purposes. Herein, we describe the zinc- or acid-mediated cross-coupling reaction of 7-azaindoles with aldehydes, such as paraformaldehyde, alkyl aldehydes, aryl aldehydes, enal, and α-ketoaldehyde, providing the corresponding C3-linked bis-7-azaindole derivatives, which are a crucial class towards the development of novel bioactive compounds. High levels of site selectivity and functional group tolerance were observed. Synthesized 3,3′-bis-7-azaindole derivatives were evaluated against human breast adenocarcinoma cells (MCF-7) and human ovarian carcinoma cells (SKOV-3), respectively. Notably, compounds 3s and 4e displayed promising anticancer properties competitive with anticancer doxorubicin as a positive control.

We also recommend Trading Suppliers and Manufacturers of BIS-(4-CHLORO-PHENYL)-(1-OXY-PYRIDIN-3-YL)-METHANOL (cas 19828-10-5). Pls Click Website Link as below: cas 19828-10-5 suppliers

Prev:Bis-coumarins; non-cytotoxic selective urease inhibitors and antiglycation agents
Next:Preparation and photophysical properties of thienothiophene functionalized difluoroboron bis-β-diketonate complexes)