Regiospecific alkylation of histidine and histamine at N-1 (τ)☆
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Add time:09/26/2019 Source:sciencedirect.com
Series of 1-alkyl histidines and histamines have been synthesized by the alkylation of the corresponding 5,6,7,8-tetrahydro-5-oxoimidazo[1,5-c]pyrimidines with alkyl halides in aprotic solvents. The method of conversion of the intermediate quaternary salt to the amino acid or amine depends on the nature of the alkyl group.
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