Microwave-assisted synthesis of 1-aryl-5-(trifluoromethyl)-1H-tetrazoles
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Add time:09/24/2019 Source:sciencedirect.com
This general protocol provides a wide variety of 5-substituted-1H-tetrazoles in good yields under mild reaction conditions. An efficient, green, and convenient method for the preparation of new 5-substituted-tetrazoles via microwave-assisted 1,3-dipolar cycloaddition reaction of N-aryl-2,2,2-trifluoroacetimidoyl chlorides and sodium azide in acetonitrile without assistance of any catalyst has been reported. The FT-IR, 19F NMR, 1H NMR, 13C NMR, HMBC spectra, elemental analysis, and single-crystal X-ray analysis confirm the structures of the products.
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