Hepatoprotection using Brassica rapa var. rapa L. seeds and its bioactive compound, Sinapine (cas 18696-26-9) thiocyanate, for CCl4-induced liver injury

Add time:09/26/2019    Source:sciencedirect.com

The hepatoprotective effect of Brassica rapa seeds was evaluated. The antioxidant activities of extracts were determined using total phenolic content, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, oxygen radical absorbance capacity (ORAC) and reducing power assays. Hepatoprotective effects were evaluated using CCl4-induced mouse liver damage animal model. Identification and quantification of the compound were based on ultra performance liquid chromatographic (UPLC) analysis. All extracts of Brassica rapa seeds exhibited high phenolic contents and strong antioxidant activities. The activities were in the order of ethanol extract ≥ 50% ethanol extract>water extract. All the three extracts showed effective hepatoprotection. They could ameliorate liver damage and improve the antioxidant defense system. Sinapine (cas 18696-26-9) thiocyanate was the main component and was hepatoprotective in a dose-dependent manner. These findings imply that Brassica rapa seeds could be developed as a functional food for hepatoprotection.

We also recommend Trading Suppliers and Manufacturers of Sinapine (cas 18696-26-9). Pls Click Website Link as below: cas 18696-26-9 suppliers

Prev:Fluorescence switching sensor for sensitive detection of Sinapine (cas 18696-26-9) using carbon quantum dots
Next:Sinapine (cas 18696-26-9) reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation)