Facile synthesis of fluoroalkylated quinolones using fluoroalk-2-ynoates as fluorinated building blocks

Add time:09/25/2019    Source:sciencedirect.com

In the presence of Na2CO3, a variety of fluoroalkylated quinolones were efficiently synthesized from isatins and fluoroalk-2-ynoates in good to excellent yields at room temperature. The reaction can proceed via two different ways with Michael adduct or isatoic anhydride as the key intermediate.

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