ArticleSynthesis of (±)-B(9a)-Homo-C-nor-3-methoxy-12-oxa-17-vinylestra-1,3,5(10)-trienes

Add time:09/10/2019    Source:sciencedirect.com

Treatment of diols, 11,12-seco-12-nor-11,13-dihydroxy-3-methoxy-17-vinylestra-1,3,5(10)-triene and the 18-fluoro-substituted derivatives, with phosphorus oxychloride led after rearrangement to (±)-B(9a)-homo-C-nor-3-methoxy-12-oxa-17-vinylestra-1,3,5(10)-triene and the 18-fluoro-substituted derivatives or (±)-11-nor-9-(2-propyl)-3-methoxy-12-oxa-17-vinylestra-1,3,5(10)-triene and the 18-fluoro-substituted derivatives. The vinyl group of the rearranged steroids has been oxidized using the Wacker process to the corresponding aldehydes.

We also recommend Trading Suppliers and Manufacturers of 3-Methoxy-1,3,5(10),9(11)-estratetren-17-one (cas 1670-49-1). Pls Click Website Link as below: cas 1670-49-1 suppliers

Prev:12 - Acetal, Homopolymer (POM Homopolymer)
Next:Stereoselective halogenation of the 16-hydroxymethyl-3-methoxy-13α-estra-1,3,5(10)-trien-17-ols and their solvolytic investigation)