Controlled synthesis of mixed molecular nanostructures from folate and deferrioxamine-Ga(III) on gold and tuning their performance for cancer cells

Add time:09/29/2019    Source:sciencedirect.com

A new strategy is developed for construction of the mixed molecular nanostructures from folic acid (FOA), a targeting agent, and deferrioxamoine-Ga(III), (DFO-Ga(III)), a theranostic agent, on gold-mercaptopropionic acid surface, Au-MPA. The strategy is focused to achieve a system in which all the active constituents of FOA; i.e., pteridine rings, p-aminobenzoeic acid, and the glutamic acid, having high affinity for folate receptor overexpressed on cancer cells; remain unreacted in adjacent to DFO-Ga(III), Au-MPA-[DFO-Ga(III)]‖-[FOA]. For this purpose, the NH2 groups of FOA and DFO-Ga(III) were attached covalently and separately to COOH of Au-MPA surface allowing all the active groups of FOA to be available for drug delivery purposes. The data obtained through several electrochemical and surface analysis techniques, supported successful construction of the designed mixed molecular nanostructures system. In addition, the results showed that the system is stable, and Ga(III) ion does not leave DFO-Ga(III) complex. The prepared surface was successfully tested for capturing of the breast cancer cells 4 T1 as a model. The measurements showed a rapid uptake kinetics (t1/2 of ~6.0 min) and efficient accessibility of the system by the cancer cells; the Rct was significantly increased in the presence of 4 T1 cells compared with blank PBS (ΔRct ~420 kΩ).

We also recommend Trading Suppliers and Manufacturers of GOLD (III) ACETATE (cas 15804-32-7). Pls Click Website Link as below: cas 15804-32-7 suppliers

Prev:Application of cellulose acetate to the selective adsorption and recovery of Au(III)
Next:Does the primary deposit affect the biogeochemical transformation of placer gold and associated biofilms?)