Synthesis, molecular structure, conformation and biological activity of Ad-substituted N-aryl-tetraoxaspiroalkanes

Add time:09/25/2019    Source:sciencedirect.com

An efficient method has been developed for the synthesis of 7′-arylspiro{adamantane-[2,3′]-(1′,2′,4′,5′,7′-tetraoxazocanes)} by the ring transformation reaction of spiro{adamantane-[2,3’]-(1′,2′,4′,5′,7′-pentaoxacane)} with arylamines in the presence of Sm(NO3)3·6H2O as the catalyst. NMR signals of the synthesized compounds were assigned considering the conformation dynamics of the tetraoxazocane ring with two rigid peroxide bonds. The structures of some of the compounds were studied by X-ray diffraction. The thermal stability of single crystal was determined by DSC method. Compounds 7′-(2-methylphenyl)spiro{adamantane-[2,3′]-(1′,2′,4′,5′,7′-tetraoxazocane)} and 7′-(4-fluorophenyl)spiro{adamantane-[2,3′]-(1′,2′,4′,5′,7′-tetraoxazocane)} exhibited cytotoxicity towards cancer cells.

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