Regular paperHigh-performance liquid chromatographic methods for separation of enantiomers of alicyclic β-amino acids☆

Add time:09/25/2019    Source:sciencedirect.com

Reversed-phase high-performance liquid chromatographic methods were developed for the separation and quantification of the enantiomers of alicyclic β-amino acids: racemic cis- and trans-2-aminocyclohexane-1-carboxylic acids (cis- and trans-ACHC) and racemic cis- and trans-2-animon-4-cyclohexene-1-carboxylic acids (cis- and trans-ACHC-ene). The enantioselective separations involved two methods: direct separation on a chiral stationary phase (Crownpak CR(+)) and separation of the diastereomers formed by pre-column derivatization with chiral derivatizing reagents: 1-fluoro-2,4-dinitrophenyl-5-l-alanine amide (Marfey's reagent) and 2,3,4,6-tetra-O-acetyl-β-d-glucopyranosylisothiocyanate. The different methods were compared in systematic chromatographic examinations. The effects of pH, mobile phase composition, organic modifier content and temperature on the separation were also investigated.

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