Fehling solution/DIPEA/hydrazine: an alternative catalytic medium for regioselective synthesis of 1,4-disubstituted-1H-1,2,3-triazoles using azide–alkyne cycloaddition reaction

Add time:09/27/2019    Source:sciencedirect.com

The development of copper catalyzed azide–alkyne cycloaddition in aqueous solvent system at room temperature is a notable contribution to the field of green chemistry. In this work, 1,4-disubstitued-1H-1,2,3-triazoles are synthesized in the Fehling solution, a widely used system in practical laboratory classes but totally unexplored in research field, with N,N-diisopropylethylamine/hydrazine without using any organic solvent under mild reaction conditions.

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