On the mechanism of the two-way oxidation of 2-Chloropurine (cas 1681-15-8) by mammalian xanthine oxidase
-
Add time:09/28/2019 Source:sciencedirect.com
2-Chloropurine (cas 1681-15-8) is attacked by mammalian xanthine oxidase simultaneously at C-6 and C-8. The ratio of the two rates (=1) is insensitive to variations of pH or temperature. Experiments with 2-chloropurine as inhibitor indicate instantaneous association of this purine with the active center of the enzyme. It is concluded that the rate-determining step, viz., conversion of ES → (ES)∗, is common to both pathways and that only in the subsequent interaction with water does the route fork.
We also recommend Trading Suppliers and Manufacturers of 2-Chloropurine (cas 1681-15-8). Pls Click Website Link as below: cas 1681-15-8 suppliers
Prev:The enzymic oxidation of 2-Chloropurine (cas 1681-15-8)
Next:Facile synthesis of 5-amino- and 7-amino-6-azaoxindole derivatives) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- The enzymic oxidation of 2-Chloropurine (cas 1681-15-8)10/01/2019
- Regular paperHigh-performance liquid chromatographic determination of (−)-β-d-2-aminopurine dioxolane and (−)-β-d-2-amino-6-chloropurine dioxolane, and their metabolite (−)-β-d-dioxolane guanine in monkey serum, urine and cerebrospinal fluid09/27/2019
- Tautomeric purine forms of 2-amino-6-chloropurine (N9H10 and N7H10): Structures, vibrational assignments, NBO analysis, hyperpolarizability, HOMO–LUMO study using B3 based density functional calculations09/26/2019
- Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent09/25/2019
- Efficient functionalization of 2-amino-6-chloropurine derivatives at C-8 via 8-lithiated species09/24/2019
