N-(3-Trimethylsilyl)propargyl amino esters via reductive amination

Add time:09/26/2019    Source:sciencedirect.com

N-Propargyl amino esters are useful starting materials in a variety of settings. General reductive amination conditions for N-(3-trimethylsily)propargylation of amino esters have been developed. These conditions demonstrated greater tolerance for nucleophilic side chains (amines and alcohols) than has been previously reported. This procedure produced a variety of N-(3-trimethylsilyl)propargyl amino esters in good to excellent yield.

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