Effects of a novel fatty acid derivative [(7E)-8-(2-naphthyl)-5,6trans-5,6-methano-7-OCTENOIC ACID (cas 18719-24-9)] on arachidonic acid metabolism in cultured cells

Add time:09/25/2019    Source:sciencedirect.com

The effects of a novel synthetic fatty acid derivative (TEI-8005: (7E)-8-(2-naphthyl)-5,6-trams-5,6-methano-7-octenoic acid) on arachidonic acid metabolism in some cultured cells were studied. The compound significantly stimulated prostaglandin,(especially prostacyclin) biosynthesis in cultured vascular cells and gastric mucosal epithelial cells, and inhibited lipoxygenase product formation in n-butyrate-treated mastocytoma. In aortic smooth muscle cells in which cyclooxygenase activitiy was reduced, it strongly stimulated prostaglandin formation in young cells with reduced cyclooxygenase activity but had less effect in aged cells. These result indicated that TEI-8005 enhanced prostaglandin formation in cells with either normal or reduced cyclooxygenase activity.

We also recommend Trading Suppliers and Manufacturers of 7-OCTENOIC ACID (cas 18719-24-9). Pls Click Website Link as below: cas 18719-24-9 suppliers

Prev:Cetirizine: A piperazine antihistamine
Next:Full Length ArticleEffects of structure of fatty acid collectors on the adsorption of fluorapatite (0 0 1) surface: A first-principles calculations)