One-pot synthesis of 2-arylbenzoxazole derivatives via Cu(I) catalyzed C–N/C–O coupling of N-(2-chloro-phenyl)-2-halo-benzamides and primary amines

Add time:09/24/2019    Source:sciencedirect.com

N-(2-Chloro-phenyl)-2-halo-benzamides (halo=I/Br/Cl) as substrates were used for the one-pot synthesis of 2-arylbenzoxazole derivatives via copper-catalyzed intermolecular C–N/intramolecular C–O couplings with primary amines. This aryl amination offers clean reaction conditions and easy work-up in good yields by using CuI as catalyst, readily available 8-hydroxyquinoline as ligand, K3PO4 as base, DMF as solvent.

We also recommend Trading Suppliers and Manufacturers of 4-AMINO-N-(2-CHLORO-PHENYL)-BENZENESULFONAMIDE (cas 19837-85-5). Pls Click Website Link as below: cas 19837-85-5 suppliers

Prev:Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
Next:Electrochemical behaviour of pyrazine derivatives: reduction of 2-hydroxy-3-phenyl-6-methylpyrazine)