Research sectionAbsorption, excretion and tissue distribution of 2-pyridinethiol-1-oxide

Add time:09/26/2019    Source:sciencedirect.com

Sodium pyrithione and zinc pyrithione, labelled with 35S, were administered to rats, rabbits and monkeys, either orally or ip. Rats with cannulated bile or thoracic ducts were used in some experiments. Excreta and carcasses were analysed for radioactivity to determine the metabolic fate of the pyrithione moiety. Both sodium and zinc pyrithione were absorbed into the circulation to the extent of 80–90%. The 35S was excreted rapidly in the urine (20–50% in 6 hr, 70–85% in 48 hr), but a moderate amount (c. 15%) was excreted in the bile. Small amounts (2–9%) of the 35S remained widely distributed in the body 72 hr after administration.

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