Regioselective reduction of N-alkyl-3-sulfonyl Glutarimide (cas 1121-89-7)s to δ-lactams. Formal synthesis of (±)-paroxetine and (±)-tacamonine☆
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Add time:09/28/2019 Source:sciencedirect.com
A convenient method for the preparation of 4- or 5-substituted 3-sulfonyl-δ-lactams via regioselective reduction of N-alkyl-3-sulfonyl glutarimides is described. Formal synthesis of (±)-paroxetine and (±)-tacamonine is also reported.
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