Research paperMixed micellization of an amphiphilic drug amitriptyline hydrochloride and surface active ionic liquids: Interfacial and micellization studies

Add time:09/25/2019    Source:sciencedirect.com

The mixed micellization behavior of surface active ionic liquids (SAILs), 1-dodecyl-3-methylimidazolium chloride, [C12mim][Cl], and 1-tetradecyl-3-methylimidazolium chloride, [C14mim][Cl] with an amphiphilic drug amitriptyline hydrochloride (AMT) have been studied using surface tension and conductance. Interfacial parameters obtained from surface tension were beneficial in deciphering the phenomenon taking place at the interface. Critical micelle concentration (cmc), and various thermodynamic parameters were achieved from conductance. The negative values of ΔGmic.∘ and ΔGad.∘ indicate the feasibility of the mixed micellization process. Rubingh and Motomura introduced theoretical model for micellar interaction parameter (βm) have been examined to investigate the interactions between AMT and the SAILs.

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