Neuromuscular blocking agents. Approaches to short-acting compounds 2. Bis-thiazolium salts

Add time:09/24/2019    Source:sciencedirect.com

A series of bis-thiazolium diesters has been prepared. All were substantially less potent than atracurium and all showed appreciable vagal blockade at neuromuscular blocking doses. N-Benzyl quaternary substituents shortened the duration of neuromuscular blockade significantly. Neuromuscular blocking potency was greater and duration of action least in bis-N-3,4,5-trimethoxybenzylthiazolium salts, though each of these effects was at its optimum at differing interquaternary chain separations.

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