New β-amino-α-trifluoromethyl alcohols and their exploration in the synthesis of trifluoromethylated imidazole derivatives

Add time:07/15/2019    Source:sciencedirect.com

Racemic and enantiomerically pure β-amino-α-trifluoromethyl alcohols were obtained via sequential nucleophilic trifluoromethylation of selected α-imino ketones, derived from arylglyoxals, and subsequent removal of the MeO or Ph(Me)CH substituent, respectively, located at the N-atom. The obtained products, containing a primary amino group, were used for the synthesis of imidazole N-oxides bearing a trifluoromethyl group as a part of the N(1)-alkyl chain. Imidazole N-oxides with an electron-withdrawing ester group at C(4) underwent spontaneous isomerization under the reaction conditions, and the corresponding imidazol-2-ones derivatives were isolated as final products.

We also recommend Trading Suppliers and Manufacturers of 1-[4-(4-METHOXYPHENYL)-1,3-THIAZOL-2-YL]-N-(4-METHYLBENZYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXAMIDE (cas 321848-19-5). Pls Click Website Link as below: cas 321848-19-5 suppliers

Prev:Structural and spectroscopic studies of Au(III) and Pd(II) chloride complexes and organometallics with 2-benzylpyridine
Next:Effect of ancillary (aminomethyl)phenolate ligand on efficacy of aluminum-catalyzed glucose dehydration to 5-hydroxymethylfurfural)