Stereoconvergent synthesis of a potent mosquito larvicide : (2E,4E,8E,10Z)-N-(2-methyl propyl)-2,4,8,10-dodecatetraeneamide

Add time:07/15/2019    Source:sciencedirect.com

First total synthesis of (2E,4E,8E,10Z)-N-(2-methyl propyl)-2,4,8,10-dodecatetraene amide (1), by the condensation of (4E,6Z)-octadienyl phenyl sulfone (2) and ethyl-4-oxobutanoate (3) followed by double elimination reaction, which involves easily accessible reagents and simple transformations is described.

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