Hydrophilic and salt responsive polymers promote depletion aggregation of bacteria

Add time:09/27/2019    Source:sciencedirect.com

Stimuli responsive, smart materials are extensively used as drug delivery carriers, antifouling surfaces, and as sensing and actuation devices. Among these materials; hydrophilic, neutral and biocompatible polymers are especially interesting for their strong water absorption properties, which makes them useful for a variety of applications in biotechnology and biomedicines. One example of neutral, hydrophilic and stimuli responsive polymer is poly(ethylene glycol) (PEG), which exhibits excellent antifouling and salt-responsive properties in solution. Herein, we present the synthesis and stimuli responsive properties of PEG-like hydrophilic polymers, and the study of their antibacterial and antifouling properties. The synthesis of novel hydrophilic vitamin B5 analogous polymers, namely poly(B5AMA), of different molecular weights and cross-linking densities is achieved by free radical polymerization method. The neutral polymers of different sizes and cross-linking densities prepared are then evaluated for their salt-responsive, antifouling and biocompatible properties in vitro.

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